The efficacy of extended infusions (EI) of β-lactam antibiotics for optimising outcomesin febrile neutropenia is unclear. We assessed whether the administration of β-lactamswas more effective in EI than in intermittent infusion (II) for the treatment of febrileneutropenia.

Fonte: Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomized, multicentre, open-label, superiority clinical trial – Clinical Microbiology and Infection

A conclusão “Our findings do not support the routine use of empirical EI of β-lactams in febrile neutropenia. Further studies should consider …” mostra que nem sempre achados farmacodinâmicos tem correspondência na prática clínica. O uso de infusões prolongadas na rotina de pacientes graves traz uma série de dificuldades logísticas e aparentemente sem melhorar desfecho.