Predicting Postherpetic Neuralgia

Erythrocyte sedimentation rate may serve as an objective predictive serum marker for development of PHN.

Fonte: Predicting Postherpetic Neuralgia

Risk of Herpes Zoster Prior to and Following Cancer Diagnosis and Treatment: A Population-Based Prospective Cohort Study.


Background: Information on the risks of herpes zoster (zoster) preceding a cancer diagnosis and the role of cancer treatment on risk is limited.

Methods: This was a prospective cohort of 241497 adults, with mean age 62.0 years at recruitment (2006-2009), linked to health datasets from 2006 to 2015. The relation between cancer diagnosis, treatment, and zoster risk was analyzed using time-varying proportional hazards models.

Results:  Over 1760 481 person-years of follow-up, 20286 new cancer diagnoses and 16350 zoster events occurred. Participants with hematological and solid cancer had higher relative risks of zoster than those without cancer (adjusted hazard ratio [aHR], 3.74 [95% confidence interval {CI}, 3.11-4.51] and 1.30 [95% CI, 1.21-1.40], respectively). Compared to those without cancer, zoster risk was also elevated prior to a hematological cancer diagnosis (aHR for 1-2 years prior, 2.01 [95% CI, 1.31-3.09]), but this was not the case for solid cancers (aHR for 1-2 years prior, 0.90 [95% CI, .75-1.07]). Compared to those without cancer, zoster risk among participants with solid cancers receiving chemotherapy was greater than in those without a chemotherapy record (aHR, 1.83 [95% CI, 1.60-2.09] and 1.16 [95% CI, 1.06-1.26], respectively).

Conclusions: For hematological cancer, increases in zoster risk are apparent in the 2 years preceding diagnosis and treatment; for solid organ cancers, the increased risk appears to be largely associated with receipt of chemotherapy.

IBD Hikes Zoster Risk, Even in the Young

These findings suggest that we should weigh the risks and benefits of HZ vaccination in IBD patients, even young ones.

Fonte: IBD Hikes Zoster Risk, Even in the Young

 IBD = doença inflamatória intestinal, ou seja, Doença de Crohn e retocolite ulcerativa.

Everything You Need to Know About Shingrix

Patients are asking for Shingrix. Know the important facts about storage, preparation, and administration, and what patients should be told before they receive this vaccine.

Fonte: Everything You Need to Know About Shingrix

Newer Shingles Vaccine Cheaper, More Effective

A novel adjuvanted herpes zoster vaccine is likely to be more effective and cheaper than the live attenuated herpes zoster vaccine, a study found.

Fonte: Newer Shingles Vaccine Cheaper, More Effective

Infelizmente ainda não há previsão de sua comercialização no Brasil

Imagem: Herpes Zooster disseminado


Paciente PVHA. Notem como as lesões extravasam a linha media. Característica desta doença em pacientes imunossuprimidos.



Risk of stroke and transient ischaemic attack after herpes zoster – Clinical Microbiology and Infection


Fonte: Risk of stroke and transient ischaemic attack after herpes zoster – Clinical Microbiology and Infection

essa associação não é nova, mas as evidências vão se acumulando.