Antibiotic Class Associated With Heart Valve Problems

 

‘Considerable reduction’ in use urged, especially with preexisting regurgitation

Fonte: Antibiotic Class Associated With Heart Valve Problems

E a lista de problemas com as quinolonas não para de aumentar …

Anúncios

Association Between Peripheral Neuropathy and Oral Fluoroquinolone or Amoxicillin-Clavulanate

This nested case-control study uses a large primary care population database in the United Kingdom to analyze the relative and absolute risk estimates of peripheral neuropathy among adults issued prescriptions for oral fluoroquinolone or amoxicillin-clavulanate antibiotics.

Fonte: Association Between Peripheral Neuropathy and Oral Fluoroquinolone or Amoxicillin-Clavulanate

Fluoroquinolone Antibiotics: Safety Communication – Increased Risk of Ruptures or Tears in the Aorta Blood Vessel in Certain Patients

 

FDA review found that fluoroquinolone antibiotics can increase the occurrence of rare but serious events of ruptures or tears in the main artery of the body, called the aorta. These tears, called aortic dissections, or ruptures of an aortic aneurysm can lead to dangerous bleeding or even death. They can occur with fluoroquinolones for systemic use given by mouth or through an injection.

Fluoroquinolones and Cardiovascular Risk: A Systematic Review, Meta-an

Fonte: Fluoroquinolones and Cardiovascular Risk: A Systematic Review, Meta-an

 Não é a primeira vez que postamos sobre esse tema, mas os dados desta revisão são para mim os mais contundentes.

FDA atualiza avisos em reações adversas para fluoroquinolonas sobre os riscos de saúde mental e de baixo nível de açúcar no sangue

FDA is requiring safety labeling changes for fluoroquinolones to strengthen the warnings about the risks of mental health side effects and serious blood sugar disturbances.

Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study

Mais um motivo, dentre vários, para usarmos quinolonas com parcimônia

Objective To investigate whether oral fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection. Design Nationwide historical cohort study using linked register data on patient characteristics, filled prescriptions, and cases of aortic aneurysm or dissection. Setting Sweden, July 2006 to December 2013. Participants 360 088 treatment episodes of fluoroquinolone use (78% ciprofloxacin) and propensity score matched comparator episodes of amoxicillin use (n=360 088). Main outcome measures Cox regression was used to estimate hazard ratios for a first diagnosis of aortic aneurysm or dissection, defined as admission to hospital or emergency department for, or death due to, aortic aneurysm or dissection, within 60 days from start of treatment. Results Within the 60 day risk period, the rate of aortic aneurysm or dissection was 1.2 cases per 1000 person years among fluoroquinolone users and 0.7 cases per 1000 person years among amoxicillin users. Fluoroquinolone use was associated with an increased risk of aortic aneurysm or dissection (hazard ratio 1.66 (95% confidence interval 1.12 to 2.46)), with an estimated absolute difference of 82 (95% confidence interval 15 to 181) cases of aortic aneurysm or dissection by 60 days per 1 million treatment episodes. In a secondary analysis, the hazard ratio for the association with fluoroquinolone use was 1.90 (1.22 to 2.96) for aortic aneurysm and 0.93 (0.38 to 2.29) for aortic dissection. Conclusions In a propensity score matched cohort, fluoroquinolone use was associated with an increased risk of aortic aneurysm or dissection. This association appeared to be largely driven by aortic aneurysm.

Fonte: Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study