Spondweni virus (SPONV) and Zika virus cause similar diseases in humans. We detected SPONV outside of Africa from a pool of Culex mosquitoes collected in Haiti in 2016. This finding raises questions about the role of SPONV as a human pathogen in Haiti and other Caribbean countries.
Não faltava mais nada!!! Um vírus que provoca uma doença semelhante ao Zika, de nome quase impronunciável, e ainda por cima transmitido pelo pernilongo comum.
Original Article from The New England Journal of Medicine — Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection
Fonte: Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection | NEJM
Does DAA-based HCV treatment reduce the risk of incident liver cancer compared to untreated HCV or interferon-based treatment?
Fonte: DAAs for HCV Infection and Risk of Incident Liver Cancer
Rhinoviruses and other picornaviruses need a human enzyme to manufacture their protein coat; a new small-molecule inhibitor blocks the enzyme and could be used one day to treat the common cold.
Original Article from The New England Journal of Medicine — Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection
Fonte: Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection | NEJM
Já vou adiantando, o resultado é desapontador. Como diria o Prof. Pardal: “de volta à prancheta”
The higher risk found in young patients may help explain the recent uptick in nephrolithiasis in children and adolescents, researchers suggested.
Como dizia o poeta…e agora, José?
Contact Precautions Don’t Help Prevent Spread of Resistant Bacteria in Hospitals, Research Finds
Fonte: Contact Precautions Don’t Help Prevent Spread of Resistant Bacteria in Hospitals, Research Finds
É importante treinar médicos para que estejam preparados para enfrentar esse novo desafio, alerta pesquisador
Background: Carbapenem-resistant Klebsiella pneumoniae infections are increasingly prevalent in North American hospitals. We describe an outbreak of carbapenem-resistant K. pneumoniae containing the blaOXA-232 gene transmitted by contaminated duodenoscopes during endoscopic retrograde cholangiopancreatography (ERCP) procedures. Methods: An outbreak investigation was performed when 9 patients with blaOXA-232 carbapenem-resistant K. pneumoniae infections were identified at a tertiary care hospital. The investigation included 2 case-control studies, review of duodenoscope reprocessing procedures, and culture of devices. Carbapenem-resistant Enterobacteriacieae (CRE) isolates were evaluated with polymerase chain reaction analysis for carbapenemase genes, and isolates with the blaOXA-232 gene were subjected to whole-genome sequencing and chromosome single-nucleotide polymorphism analysis. On recognition of ERCP as a key risk factor for infection, targeted patient notification and CRE screening cultures were performed. Results: Molecular testing ultimately identified 17 patients with blaOxa-232 carbapenem-resistant K. pneumoniae isolates, including 9 with infections, 7 asymptomatic carriers who had undergone ERCP, and 1 additional patient who had been hospitalized in India and was probably the initial carrier. Two case-control studies established a point-source outbreak associated with 2 specific duodenoscopes. A field investigation of the use, reprocessing, and storage of deuodenoscopes did not identify deviations from US Food and Drug Administration or manufacturer recommendations for reprocessing. Conclusions: This outbreak demonstrated the previously underappreciated potential for duodenoscopes to transmit disease, even after undergoing high-level disinfection according to manufacturers’ guidelines.
Combination therapy was not superior to monotherapy. The addition of meropenem tocolistin did not improve clinical failure in severe A baumannii infections. The trialwas unpowered to specifically address other bacteria.
blog infectologia em geral 