In this cohort study, the risk for MI hospitalization within 1 week was also raised if respiratory specimens pointed to infections by several viruses not related to influenza.
Fonte: Lab-Confirmed Flu Virus Linked to Imminent Risk for Acute MI
Resultados instigantes. O risco de IAM é maior nos 7 dias seguintes a um diagnóstico de gripe!!!
Mortality in patients with sepsis is lower for those who receive prolonged intravenous infusions of antipseudomonal beta-lactams than for those who receive short-term infusions, according to a systematic review and meta-analysis of randomized trials.
Fonte: Prolonged Beta-lactam Infusion Better for Patients With Sepsis
Estudo brasileiro, publicado na revista Lancet (edição eletrônica), sobre a associação entre Zika e microcefalia, bem como descartando outros fatores externos (vacinas, contato com larvicidas) como fatores coadjuvantes.
The aim was to aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care. A cohort of 28 883 adult patients with acute cough attributed to lower respiratory tract infections (LRTIs) was recruited from 5222 UK practices in 2009–13. Symptoms, signs and treatment were recorded at presentation and subsequent events followed-up for 30 days by chart review. The predictive value of patient characteristics, presenting symptoms and clinical findings for the diagnosis of pneumonia in the first 7 days was established. Of the 720 out of 28 883 (2.5.%) radiographed within 1 week of the index consultation, 115 (16.0%; 0.40% of 28 883) were assigned a definite or probable pneumonia diagnosis. The significant independent predictors of radiograph-confirmed pneumonia were temperature >37.8°C (RR 2.6; 95% CI 1.5–4.8), crackles on auscultation (RR 1.8; 1.1–3.0), oxygen saturation 100·min–1 (RR 1.9; 1.1–3.2). Most patients with pneumonia (99/115, 86.1%) exhibited at least one of these four clinical signs; the positive predictive value of having at least one of these signs was 20.2% (95% CI 17.3–23.1). In routine practice, radiograph-confirmed pneumonia as a short-term complication of LRTI is very uncommon (one in 270). Pulse oximetry may aid the diagnosis of pneumonia in this setting. Pulse oximetry probably has a role in the diagnosis of pneumonia in the community
Acesse o texto do Medscape em português aqui
Pacientes hospitalizados, críticos ou não, que recebem soluções cristaloides balanceadas têm chances 1% menores de precisar de terapia de reposição renal, apresentar disfunção renal persistente ou morrer no hospital do que pacientes que recebem solução salina, mostram dois novos estudos de referência.
Dengue virus causes vascular leak through its nonstructural protein 1 (NS1)-mediated disruption of endothelial glycocalyx components, researchers report.
Fonte: How Severe Dengue Infection Causes Vascular Leakage
Interessante! O senso comum sempre foi entender a fragilidade capilar na Dengue como resultado da ação das citocinas inflamatórias, mas esse estudo – de conclusões preliminares é bom frisar – sugere que a agressão se dá por ação direta da partícula NS1 produzida pelo vírus, e que inclusive é usada para diagnóstico precoce de Dengue.
This population-based cohort study investigates the risk of mental disorders, specifically obsessive-compulsive disorder and tic disorders, after a streptococcal throat infection.
Fonte: Association of Streptococcal Throat Infection With Mental Disorders
Mais essa agora!!
This review provides an update on the available management strategies for congenital cytomegalovirus infection and discusses promising new treatment options.
Fonte: Congenital Cytomegalovirus Infection: Management Update
Skin and soft tissue infections (SSTIs) carry significant economic burden, as wellas morbidity and mortality, especially when caused by methicillin-resistant Staphylococcusaureus (MRSA). Several new MRSA-active antibiotics have been developed, includingsemisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancinand oritavancin offer extended dosing intervals.
blog infectologia em geral 