Did Caravaggio die of Staphylococcus aureus sepsis?



Acesse aqui a pagina do Face do Lancet

Converging elements supporting this hypothesis also showed that this death is plausible in the context of Caravaggio’s life and resulted from sepsis secondary to superinfection of wounds after a fight in Naples, a few days before the onset of symptoms.

Dica retirada da pagina do Face de nosso amigo Rodrigo Angerami, do serviço de infectologia do HC UNICAMP.

Are coagulase-negative staphylococci virulent?


BACKGROUND: Progress in contemporary medicine is associated with an increasing number of immunocompromised individuals. In this vulnerable group, the underlying disease together with long-term hospitalization and the use of medical devices facilitate infections by opportunistic pathogens for which coagulase-negative staphylococci (CoNS) represent a prime example.

OBJECTIVES: The diversity of CoNS with species- and strain-specific differences concerning virulence and clinical impact is highlighted. A focus will be on the ability of CoNS to generate biofilms on biotic and abiotic surfaces, which enables skin and mucosa colonization as well as establishment of CoNS on indwelling foreign bodies.

SOURCES: Literature about the virulence of CoNS listed in PubMed has been reviewed.

CONTENT: The vast majority of catheter-related and prosthetic joint infections as well as most other device-related infections are caused by CoNS, specifically by Staphylococcus epidermidis and Staphylococcus haemolyticus. A common theme of CoNS infections is a high antibiotic resistance rate which often limits treatment options and contributes to the significant health and economic burden imposed by CoNS.

IMPLICATIONS: Breaching the skin barrier along with the insertion of medical devices offers CoNS opportunities to get access to host tissues and to sustain there by forming biofilms on foreign body surfaces. Biofilms represent the perfect niche to protect CoNS from both the host immune response and the action of antibiotics. Their particular lifestyle combined with conditions that facilitate host colonization and infection led to the growing impact of CoNS as pathogens. Moreover, CoNS may serve as hidden reservoirs for antibiotic resistance and virulence traits.

Safety of Anti-Staphylococcal Penicillins versus Cefazolin: A Systematic Review and Meta-Analysis

Cefazolina parece ser uma opção de primeira linha mais segura – vs. penicilinas antiestafilocócicas – para pacientes com infecção por MSSA, de acordo com uma revisão sistemática e meta-análise envolvendo estudos de internação e ambulatorial. Em comparação com as penicilinas, a cefazolina foi associada a menor nefrotoxicidade, hepatotoxicidade, nefrite intersticial e reações de hipersensibilidade.

Fonte: Safety of Anti-Staphylococcal Penicillins versus Cefazolin: A Systematic Review and Meta-Analysis

(Somente o resumo – em inglês)