Surviving Sepsis Campaign: International Guidelines for Man… : Critical Care Medicine

 

Surviving Sepsis Campaign

Fonte: Surviving Sepsis Campaign: International Guidelines for Man… : Critical Care Medicine

link para o documento completo. Em inglês e extenso!

Recognizing Sepsis as a Global Health Priority — A WHO Resolution — NEJM

Perspective from The New England Journal of Medicine — Recognizing Sepsis as a Global Health Priority — A WHO Resolution

Fonte: Recognizing Sepsis as a Global Health Priority — A WHO Resolution — NEJM

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis — NEJM

Original Article from The New England Journal of Medicine — Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

Fonte: Time to Treatment and Mortality during Mandated Emergency Care for Sepsis — NEJM

Video-animação do ILAS sobre Sepsis.

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Se só faltava desenhar, agora não falta nada. Animação bem simplesinha sobre sepsis, do ILAS. Bom para leigos.

Controvérsias na nova definição de Sepsis

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Acesse o Medscape por aqui

Definitivamente a nova definição de sepsis, publicada recentemente no JAMA não foi uma unanimidade. Este editorial do Medscape explora esta polêmica.

Severe Sepsis and Septic Shock Associated with Chikungunya Virus Infection, Guadeloupe, 2014 – Volume 22, Number 5—May 2016 – Emerging Infectious Disease journal – CDC

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During a 2014 outbreak, 450 patients with confirmed chikungunya virus infection were admitted to the University Hospital of Pointe-à-Pitre, Guadeloupe. Of these, 110 were nonpregnant adults; 42 had severe disease, and of those, 25 had severe sepsis or septic shock and 12 died. Severe sepsis may be a rare complication of chikungunya virus infection.

Fonte: Severe Sepsis and Septic Shock Associated with Chikungunya Virus Infection, Guadeloupe, 2014 – Volume 22, Number 5—May 2016 – Emerging Infectious Disease journal – CDC

Preocupante, muito preocupante…

Diferentes resultados em Sepsis com diferentes soluções de cristalóides?

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Via Medscape 

É o primeiro trabalho que leio em que soluções balanceadas de cristalóides tem resultado superior ao SF na ressucitação da Sepsis. Será assim mesmo?

Procalcitonin-guided antibiotic treatment in critically ill patients | Read by QxMD

PURPOSE: In critically ill patients, length of antibiotic treatment can be effectively guided by procalcitonin (PCT) protocols. International sepsis guidelines and guidelines on antibiotic stewardship strategies recommend PCT as helpful laboratory marker for a rational use of antibiotics. A number of studies and meta-analyses have confirmed the effectiveness of PCT-protocols for shortening antibiotic treatment without compromising clinical outcome in critically ill patients. But in clinical practice, there is still uncertainty how to interpret PCT levels and how to adjust antibiotic treatment in various infectious situations, especially in the perioperative period. METHODS: This narrative review gives an overview on the application of PCT-protocols in critically ill patients with severe bacterial infections on the basis of 5 case reports and the available literature. Beside strengths and limitations of this biomarker, also varying kinetics and different maximum values with regard to the infectious focus and pathogens are discussed. RESULTS: PCT-guided antibiotic treatment appears to be safe and effective. Most of the studies revealed a shorter antibiotic treatment without negative clinical outcomes. Cost effectiveness is still a matter of debate and effects on bacterial resistance due to shorter treatments, possible lower rates of drug-related adverse events, or decreased rates of Clostridium difficile infections are not yet evaluated. CONCLUSION: Guidance of antibiotic treatment can effectively be supported by PCT-protocols. However, it is important to consider the limitations of this biomarker and to use PCT protocols along with antibiotic stewardship programmes and regular clinical rounds together with infectious diseases specialists.

Fonte: Procalcitonin-guided antibiotic treatment in critically ill patients | Read by QxMD

O uso da procalcitonina e não da PCR é o “standart of care” da utilidade dos biomarcadores no manejo de antimicrobianos em pacientes sépticos.