The advent of combination antiretroviral therapy (ART) has significantly decreased AIDS-related morbidity and mortality. Nevertheless, the benefits of ART are only realized through adherence to lifelong treatment. Though contemporary antiretroviral (ARV) drugs have fewer adverse effects in comparison to older ARV drugs, many agents are associated with negative or unknown long-term effects. There is increasing evidence that two-drug (dual-therapy) regimens may be an effective alternative to the currently recommended three-drug (triple-therapy) regimens. In this review, we provide a comprehensive and critical review of recently completed and ongoing trials of dual-therapy regimens in treatment-naïve and treatment-experienced HIV-1-infected patients. We also review current HIV/AIDS society recommendations regarding dual therapy as well as future therapeutic possibilities.
Fonte: Two-Drug Treatment Approaches in HIV: Finally Getting Somewhere? | Read by QxMD
Aterapia antiretroviral tripla é um dos mais sólidos pilares da nossa especislidade. Será que chegou a hora de rever nossos conceitos?
Antes da introdução da TARV o SK era uma das manifestações oportunistas mais frequentes. Depois da introdução da TARV a incidência caiu muito. Este estudo analisa o impacto da introdução da terapia no risco de desenvolver a lesão. 
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